Huijin Lee

PhD Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 2025 
MS Chemistry, Johns Hopkins University, 2019 
B.S. Chemical Education, Seoul National University, 2017 

Research Interests 

Mammalian synthetic biology, biophysical principles in mammalian genetic systems, synthetic genetic circuits 

Publications 

• Lee, H., Ha, T. et al. (2025) A high throughput single molecule platform to study DNA supercoiling effect on protein-DNA interactions. Nucleic acids research, 53, 581. 

• Hwang, J., Lee, C., Brahmachari, S., Tripathi, S., Paul, T., Lee, H., et al (2025) DNA supercoiling-medicated G4/R-loop formation tunes transcription by controlling the access of RNA polymerase, Nature communication, 16, 3363  

• Yuhas, S. C., Laverty, D. J., Lee, H., Majumdar, A., Greenberg, M. M. (2021) Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor. Journal of the American Chemical Society, 143(21), 8099-8107. 

Beyond the lab 

Tennis, Baking, Sunset strolls 

Contact 

leeh333(at) mit.edu