The Galloway Lab connects basic research questions in gene circuits, genome architecture, and cell fate transitions to tool development for biomedical applications.
We construct synthetic gene circuits as model chromatin systems to understand the biophysical basis of gene regulation and the resulting impact of feedback on transcriptional networks. In conjunction with our circuit work, we are interested in defining the molecular rules of cell fate transitions. With these insights, we construct regulatory circuits that interface with native networks, optimize cellular reprogramming, and track cell fate transitions. Ultimately, we aim to develop the next generation of integrated genomic circuits capable of tasks such as tissue regeneration and surveillance of pathological states.